Human choline dehydrogenase: Medical promises and biochemical challenges
Human choline dehydrogenase (CHD) is located in the inner membrane of mitochondria
primarily in liver and kidney and catalyzes the oxidation of choline to glycine betaine. Its
physiological role is to regulate the concentrations of choline and glycine betaine in the
blood and cells. Choline is important for regulation of gene expression, the biosynthesis of
lipoproteins and membrane phospholipids and for the biosynthesis of the neurotransmitter
acetylcholine; glycine betaine plays important roles as a primary intracellular …
primarily in liver and kidney and catalyzes the oxidation of choline to glycine betaine. Its
physiological role is to regulate the concentrations of choline and glycine betaine in the
blood and cells. Choline is important for regulation of gene expression, the biosynthesis of
lipoproteins and membrane phospholipids and for the biosynthesis of the neurotransmitter
acetylcholine; glycine betaine plays important roles as a primary intracellular …
